Mechanism of paeonol combined with paeoniflorin against myocardial ischemia injury:based on proteomics.
10.19540/j.cnki.cjcmm.20210615.701
- Author:
Chun-Yan HU
1
;
Xin GUO
1
;
Xue-Ling LIU
1
;
Gang LIU
1
;
Xiao XU
1
;
Qing MAO
2
;
Qi GUO
1
Author Information
1. Jiangsu University Zhenjiang 212013, China.
2. Nanjing Lishui People's Hospital Nanjing 211200, China.
- Publication Type:Journal Article
- Keywords:
differential proteomics;
myocardial ischemia injury;
paeoniflorin;
paeonol
- MeSH:
Acetophenones;
Animals;
Glucosides;
Monoterpenes;
Myocardial Ischemia/genetics*;
Myocardial Reperfusion Injury;
Proteomics;
Rats;
Rats, Sprague-Dawley
- From:
China Journal of Chinese Materia Medica
2021;46(15):3943-3948
- CountryChina
- Language:Chinese
-
Abstract:
The study aims to investigate the effect of the compatibility of paeonol and paeoniflorin(hereinafter referred to as the compatibility) on the expression of myocardial proteins in rats with myocardial ischemia injury and explore the underlying mechanism of the compatibility against myocardial ischemia injury. First, the acute myocardial infarction rat model was established by ligation of the anterior descending branch of the left coronary artery. The model rats were given(ig) paeonol and paeoniflorin. Then protein samples were collected from rat cardiac tissue and quantified by tandem mass tags(TMT) to explore the differential proteins after drug intervention. The experimental results showed that differential proteins mainly involved phagocytosis engulfment, extracellular space, and antigen binding, as well as Kyoto encyclopedia of genes and genomes(KEGG) pathways of complement and coagulation cascades, syste-mic lupus erythematosus, and ribosome. In this study, the target proteins and related signaling pathways identified by differential proteomics may be the biological basis of the compatibility against myocardial ischemia injury in rats.
