Chemical constituents of Psidium guajava and their antitumor and antifungal activities.
10.19540/j.cnki.cjcmm.20210517.202
- Author:
Xiao-Cong LIU
1
;
Dong-Mei LIN
1
;
Min LIU
1
;
Min ZHANG
1
;
Qiang LI
1
;
Jian WANG
1
;
Lu-Lin XU
1
;
Yuan GAO
1
;
Jian YANG
2
Author Information
1. Faculty of Materials and Chemical Engineering, Yibin University Yibin 644000, China.
2. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Psidium guajava;
antifungal activity;
antitumor activity;
chemical constituent;
meroterpenoid
- MeSH:
Antifungal Agents/pharmacology*;
Humans;
Magnetic Resonance Spectroscopy;
Plant Extracts;
Plant Leaves;
Psidium;
Terpenes
- From:
China Journal of Chinese Materia Medica
2021;46(15):3877-3885
- CountryChina
- Language:Chinese
-
Abstract:
Twenty-six compounds, including sixteen meroterpenoids(1-16), a triterpenoid(17), four terpenoid derivatives(18-21), and five aromatic compounds(22-26), were isolated from the leaves of Psidium guajava. Their structures were identified by spectroscopic analyses including NMR and MS. Compounds 21-26 were obtained from plants of Psidium for the first time. Based on the structure,(R)-2-ethylhexyl 2H-1,2,3-triazole-4-carboxylate(24 a), an α-glucosidase inhibitor recently isolated from Paramignya trimera, should be revised as compound 24. Meroterpenoids 1-16 were evaluated for their antitumor and antifungal activities. Meroterpenoids psiguajadial D(4), guapsidial A(5), 4,5-diepipsidial A(7), guadial A(14), and guadial B(15) showed cytotoxicities against five human tumor cell lines(HL-60, A-549, SMMC-7721, MCF-7, and SW-480), among which 5 was the most effective with an IC_(50) of 3.21-9.94 μmol·L~(-1).
