Study on synergistic effect of Qingkailing Injection and Shengmai Injection on organ injury in endotoxemia rats.
10.19540/j.cnki.cjcmm.20210524.404
- Author:
Yan YI
1
;
Chun-Ying LI
1
;
Yong ZHAO
1
;
Jing-Zhuo TIAN
1
;
Lian-Mei WANG
1
;
Chen PAN
1
;
Ai-Hua LIANG
1
Author Information
1. Key Laboratory of Beijing for Identification and Safety of Chinese Medicine, State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sceiences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Qingkailing Injection;
Shengmai Injection;
combination medication;
endotoxemia;
organ protection
- MeSH:
Animals;
Drug Combinations;
Drugs, Chinese Herbal;
Endotoxemia/drug therapy*;
Rats
- From:
China Journal of Chinese Materia Medica
2021;46(16):4193-4200
- CountryChina
- Language:Chinese
-
Abstract:
As a dangerous disease with rapid progression, endotoxemia is easy to induce the damage to multiple organs. However, its specific and efficient treatment methods are still lacking at present. Both Qingkailing Injection(QKLI) and Shengmai Injection(SMI) have been proved effective in anti-inflammation, anti-endotoxin and organ protection. In this study, carrageenan and endotoxin were injected successively into rats to establish an endotoxemia model. Different doses of QKLI and SMI were administered to the endotoxemia rats by intraperitoneal injection separately or in combination. Then the count of white blood cells, the number of platelets, the content of cytokines, biochemical indexes, organ coefficient and pathological changes of main organs in the rats were detected. The results showed that the rats in the model group had obvious symptoms of endotoxemia, i.e., leucopenia, thrombocytopenia, increase in cytokines(IL-6 and TNF-α) and biochemical indexes of liver and kidney function as well as pathological damage to liver, kidney and lung. QKLI alone can alleviate the above symptoms of endotoxemia and the organ injury. SMI alone is less effective in improving disseminated intravascular coagulation(DIC) and cytokine secretion complicated with endotoxemia, but capable of reducing the inflammation degree of the lung, liver and kidney. The combination of QKLI and SMI remarkably increased the number of platelets in the peripheral blood, improved the liver and kidney function and reduced inflammatory factors, with lung, liver, kidney and other organ structures protected well. Moreover, the improvement effect of the combination of QKLI and SMI was stronger than those of the two injections alone at fixed doses, indicative of a synergistic effect.
