Research progress in establishment of N-methyl-N'-nitro-N-nitroso-guanidine-induced rat model of Precancerous lesion of gastric cancer.
10.19540/j.cnki.cjcmm.20210316.601
- Author:
Yu-Ting LU
1
;
Hua-Yi LIU
2
;
Jia-Ju SHANG
2
;
Yi-Jia MAO
1
;
Guang-Ze OUYANG
1
;
Liu YANG
2
Author Information
1. Tianjin University of Traditional Chinese Medicine Tianjin 301608, China.
2. Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120, China.
- Publication Type:Journal Article
- Keywords:
MNNG-induction;
animal model;
gastric cancer(GC) and precancerous lesion of gastric cancer(PLGC)
- MeSH:
Animals;
Gastric Mucosa;
Methylnitronitrosoguanidine/toxicity*;
Precancerous Conditions/chemically induced*;
Rats;
Stomach Neoplasms/drug therapy*
- From:
China Journal of Chinese Materia Medica
2021;46(16):4089-4095
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer(GC), one of the most common malignancies worldwide, seriously threatens human health due to its high morbidity and mortality. Precancerous lesion of gastric cancer(PLGC) is a critical stage for preventing the occurrence of gastric cancer, and PLGC therapy has frequently been investigated in clinical research. Exploring the proper animal modeling methods is necessary since animal experiment acts as the main avenue of the research on GC treatment. At present, N-methyl-N'-nitro-N-nitroso-guanidine(MNNG) serves as a common chemical inducer for the rat model of GC and PLGC. In this study, MNNG-based methods for modeling PLGC rats in related papers were summarized, and the applications and effects of these methods were demonstrated by examples. Additionally, the advantages, disadvantages, and precautions of various modeling methods were briefly reviewed, and the experience of this research group in exploring modeling methods was shared. This study is expected to provide a reference for the establishment of MNNG-induced PLGC animal model, and a model support for the following studies on PLGC.
