Separation and structural elucidation of C25 epimers of furostanol saponin from aerial parts of Paris polyphylla var. chinensis.
10.19540/j.cnki.cjcmm.20210623.302
- Author:
Xiao-Min TAN
1
;
Liang-Jun GUAN
2
;
Yun-Ge FANG
1
;
Yan-Min LI
2
;
Zi-Lu ZHENG
2
;
Liang-Mian CHEN
2
;
Hui-Min GAO
2
;
Zhi-Min WANG
2
Author Information
1. Tianjin University of Traditional Chinese Medicine Tianjin 300193, China National Engineering Laboratory of Quality Control Technology of Chinese Materia Medica, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. National Engineering Laboratory of Quality Control Technology of Chinese Materia Medica, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Paridis Rhizoma;
Paris polyphylla var.chinensis;
aerial parts;
epimer;
furostanol saponins;
steroidal saponins
- MeSH:
Liliaceae;
Melanthiaceae;
Plant Extracts;
Rhizome;
Saponins
- From:
China Journal of Chinese Materia Medica
2021;46(16):4023-4033
- CountryChina
- Language:Chinese
-
Abstract:
Paris polyphylla var. chinensis(PPC) is used as one of the origin plants of Paridis Rhizoma described in the Chinese Pharmacopoeia(2020 edition). Its resources shortage makes the planting scale gradually expand, and plenty of aerial parts are abandoned because of not being effectively used. On the basis of previous research, this study separated steroidal saponins to further clarify the chemical composition of the aerial parts of PPC. As a result, three pairs of 25R or 25S epimers of furostanol saponins were obtained by various column chromatography techniques. Their structures were identified as neosolanigroside Y6(1), solanigroside Y6(2), neoprotogracillin(3), protogracillin(4), neoprotodioscin(5) and protodioscin(6) by spectral data combining with chemical transformation. Compound 1 is a new compound, and compounds 2, 3 and 5 are isolated from Paris plants for the first time. Compounds 4 and 6 are isolated from this plant for the first time. Previously, only several spirostanol glycosides with 25S configuration were isolated from Paris plants. Guided by mass spectrometry, the present study isolated the furostanol saponins with 25S configuration from this genus for the first time, which further enriches the chemical information of Paris genus and provides a reference for the isolation of similar compounds.
