Nucleic acid aptamer-based traditional Chinese medicine application:therapy,targeting and diagnosis.
10.19540/j.cnki.cjcmm.20210308.603
- Author:
Hong-Qian KUI
1
;
Chen-Xi LI
1
;
Yu-Rong SONG
1
;
Guang-Zhi LIU
1
;
Rui LIU
1
;
You-Wen CHEN
1
;
Yuan-Yan LIU
1
Author Information
1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100102, China.
- Publication Type:Journal Article
- Keywords:
disease diagnosis;
nucleic acid aptamer;
targeted delivery;
targeted therapy;
traditional Chinese medicine
- MeSH:
Aptamers, Nucleotide;
Drug Delivery Systems;
Medicine, Chinese Traditional;
Nucleic Acids;
RNA, Small Interfering
- From:
China Journal of Chinese Materia Medica
2021;46(12):3165-3170
- CountryChina
- Language:Chinese
-
Abstract:
Nucleic acid aptamers, broad-spectrum target-specific single-stranded oligonucleotides, serve as molecules in targeted therapy, targeted delivery and disease diagnosis for the treatment of tumor or microbial infection and clinical detection. Due to the existence of components in the use of traditional Chinese medicine(TCM), the target is difficult to concentrate and the specificity of treatment is poor. The effective components of TCM are toxic components, so a highly sensitive detection method is urgently needed to reduce the toxicity problem at the same time. The combined application of TCM and modern medical treatment strategy are difficult and cannot improve the therapeutic effect. Aptamers, advantageous in biosensors, aptamer-nanoparticles for targeted drug delivery, and aptamer-siRNA chimeras, are expected to connect Chinese medicinals with nanotechnology, diagnostic technology and combined therapies. We summarized the preparation, screening, and modification techniques of nucleic acid aptamers and the biomedical applications and advantages in therapy, targeting, and diagnosis, aiming at providing a reference for the in-depth research and development in TCM.
