Triterpenoids from leaves of Ilex guayusa.
10.19540/j.cnki.cjcmm.20210317.601
- Author:
Hui HUANG
1
;
Ye CHEN
1
;
Hu-Hu ZENG
1
;
Xiao-Jun HUANG
1
;
Lei WANG
1
;
Ying WANG
1
;
Zhi-Guo MA
1
;
Xiao-Qi ZHANG
2
;
Chun-Lin FAN
2
;
Wen-Cai YE
2
Author Information
1. Center for Bioactive Natural Molecules and Innovative Drugs Research, College of Pharmacy, Jinan University Guangzhou 510632, China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University Guangzhou 510632, China.
2. Center for Bioactive Natural Molecules and Innovative Drugs Research, College of Pharmacy, Jinan University Guangzhou 510632, China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University Guangzhou 510632, China NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine(Traditional Chinese Patent Medicine) Guangzhou 510632, China.
- Publication Type:Journal Article
- Keywords:
Aquifoliaceae;
Ilex guayusa;
chemical constituents;
triterpenoids
- MeSH:
Drugs, Chinese Herbal;
Ilex guayusa;
Molecular Structure;
Oleanolic Acid;
Plant Leaves;
Triterpenes
- From:
China Journal of Chinese Materia Medica
2021;46(12):3123-3132
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents from the leaves of Ilex guayusa were investigated. Sixteen triterpenoids were isolated from the 95% ethanol extract of dried leaves of I. guayusa by silica gel, Sephadex LH-20, and ODS column chromatographies and semi-prepa-rative HPLC. Those triterpenoids were identified by NMR, HR-MS, and literature analysis: 3β-hydroxy-11α,12α-epoxy-24-nor-urs-4(23)-ene-28,13β-olide(1), 3β-hydroxy-24-nor-4(23),12-oleanadien-28-methyl ester(2), oleanolic acid(3), 3β,28-dihydroxy-12-oleanene(4), 2α,3β-dihydroxy-11α,12α-epoxy-24-'nor-olean-4(23)-ene-28,13β-olide(5), ursolic acid(6), 3β,23-dihydroxy ursolic acid(7), 3β,28-dihydroxy-12-ursene(8), 3β-28-nor-urs-12-ene-3,17-diol(9), 3β-hydroxyurs-11-ene-28,13β-olide(10), 13β,28-epoxy-3β-hydroxy-11-ursene(11), 3β-hydroxy-28,28-dimethoxy-12-ursene(12), 3β-hydroxy-24-nor-urs-4(23),12-dien-28-oic acid(13), 3β-hydroxy-24-nor-urs-4(23),12-dien-28-methyl ester(14), 2α,3β-dihydroxy-11α,12α-epoxy-24-nor-urs-4(23)-ene-28,13β-olide(15) and 2α,3β-dihydroxy-11α,12α-epoxy-24-nor-urs-4(23),20(30)-dien-28,13β-olide(16). Compounds 1-2 were new compounds, and compounds 4-5, 7 and 9-16 were isolated from I. guayusa for the first time.
