Overview of systematic reviews on Shuxuening Injection.
10.19540/j.cnki.cjcmm.20201201.501
- Author:
Ya GAO
1
;
Ming LIU
1
;
Shu-Zhen SHI
1
;
Ke-Lu YANG
2
;
Jin-Hui TIAN
3
Author Information
1. Evidence-based Medicine Center,Lanzhou University Lanzhou 730000,China School of Basic Medical Sciences,Lanzhou University Lanzhou 730000,China.
2. Evidence-based Medicine Center,Lanzhou University Lanzhou 730000,China.
3. Evidence-based Medicine Center,Lanzhou University Lanzhou 730000,China School of Basic Medical Sciences,Lanzhou University Lanzhou 730000,China Key Laboratory of Evidence-based Medicine and Knowledge Translation of Gansu Province,Lanzhou University Lanzhou 730000,China.
- Publication Type:Meta-Analysis
- Keywords:
AMSTAR 2;
Meta-analysis;
Shuxuening Injection;
adverse reaction;
efficacy;
overview of systematic reviews
- MeSH:
Angina Pectoris/drug therapy*;
Drugs, Chinese Herbal;
Humans;
Injections;
Salvia miltiorrhiza;
Systematic Reviews as Topic
- From:
China Journal of Chinese Materia Medica
2021;46(14):3712-3721
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to analyze the methodological quality of systematic reviews of Shuxuening Injection and evaluate the efficacy and adverse reactions of Shuxuening Injection in the treatment of different diseases,in order to provide supportive evidence for clinical practice. Three Chinese databases and three English databases were retrieved to identify systematic reviews and Meta-analysis on the efficacy and safety of Shuxuening Injection in the treatment of diseases. The AMSTAR 2( a measurement tool to assess systematic reviews 2) tool was used to evaluate the methodological quality of the included systematic reviews,and tables were created to present the results of Meta-analyses. Twenty-four systematic reviews were included,all with very low methodological quality. Among the 16 AMSTAR-2 items,only 5 items had a compliance rate greater than 60. 0%,and 8 items had a compliance rate less than 50. 0%. For patients with cerebral infarction,Shuxuening Injection combined with conventional treatment was more effective than conventional treatment alone in terms of clinical efficiency and neurological deficit improvement. For patients with angina pectoris,Shuxuening Injection was superior to Danshen/Compound Danshen Injection in terms of the total effective rate of angina pectoris and total effective rate of ECG. The efficacy of Shuxuening Injection combined with conventional treatment is significantly better than conventional treatment.Shuxuening Injection( alone or combined with conventional treatments) was better than conventional treatments for cerebral hemorrhage,ischemic cerebrovascular disease,chronic pulmonary heart disease,vertigo and sudden deafness. Shuxuening Injection had better efficacy and lower incidence of adverse reactions,but the methodological quality of included systematic reviews was low. The results of this study still need to be verified by high-quality systematic reviews.
