Chemical constituents from the leaves of Cinnamomum camphora var. linaloolifera and their anti-inflammatory activities.
10.19540/j.cnki.cjcmm.20210318.602
- Author:
Mei-Ting WU
1
;
Shi-Yao LIU
1
;
Da-Long HUANG
2
;
Li-Na HE
1
;
Mao GUO
1
;
Lin NI
3
;
Shuang-Quan ZOU
4
Author Information
1. College of Plant Protection,Fujian Agriculture and Forestry University Fuzhou 350000,China.
2. Forestry Science and Technology Extension Station of Nan'an City Quanzhou 362000,China.
3. College of Plant Protection,Fujian Agriculture and Forestry University Fuzhou 350000,China Fujian Colleges and Universities Engineering Research Institute of Conservation & Utilization of Natural Bioresources Fuzhou 350000,China.
4. Fujian Colleges and Universities Engineering Research Institute of Conservation & Utilization of Natural Bioresources Fuzhou 350000,China.
- Publication Type:Journal Article
- Keywords:
Cinnamomum camphora var.linaloolifera;
anti-inflammatory activities;
chemical constituents
- MeSH:
Anti-Inflammatory Agents/pharmacology*;
Cinnamomum;
Cinnamomum camphora;
Plant Leaves
- From:
China Journal of Chinese Materia Medica
2021;46(14):3592-3598
- CountryChina
- Language:Chinese
-
Abstract:
Thirteen compounds were isolated and purified from the leaves of Cinnamomum camphora by the macroporous resin,silica gel,and Sephadex LH-20 column chromatographies. Those compounds were further identified by IR,UV,MS,and NMR techniques:( 2 S)-1-( 3″,4″-methylenedioxy phenyl)-3-( 2',6'-dimethoxy-4'-hydroxyphenyl)-propan-2-ol( 1),( 2 R,3 R)-5,7-dimethoxy-3',4'-methylenedioxy flavanol( 2),9-hydroxysesamin( 3),sesamin( 4),piperitol( 5),kobusin( 6),(-)-aptosimon( 7),acuminatolide( 8),1β,11-dihydroxy-5-eudesmene( 9),lasiodiplodin( 10),vanillin( 11),p-hydroxybenzaldehyde( 12),and p-hydroxybenzoic acid ethyl ester( 13). Compound 1 was a novel compound,and compounds 2,6,7,9 and 10 were isolated from Cinnamomum plants for the first time. Compounds 4,7 and 10 were found to possess good inhibitory effect on IL-6 production in LPS-induced BV2 cells at a concentration of 20 μmol·L-1 in the in vitro bioassay,with inhibition rates of 51. 26% ± 4. 13%,67. 82% ± 3. 77% and85. 81%±1. 19%,respectively.
