Network Meta-analysis of clinical efficacy of Chinese herbal injection in adjuvant treatment of unstable angina pectoris.
10.19540/j.cnki.cjcmm.20210506.501
- Author:
Fei-Fan JIA
1
;
Zi-Xin LIU
1
;
Shu-Juan XU
2
;
Gao-Jie XIN
1
;
Xiao HAN
1
;
Lei LI
1
;
Hao GUO
1
;
Hong-Xu MENG
1
;
Jian-Xun LIU
1
;
Jian-Hua FU
1
Author Information
1. Institute of Basic Medicine,Xiyuan Hospital,Chinese Academy of Chinese Medical Sciences Beijing 100091,China National Clinical Research Center of Cardiovascular Disease of Traditional Chinese Medicine Beijing 100091,China.
2. Institute of Basic Medicine,Xiyuan Hospital,Chinese Academy of Chinese Medical Sciences Beijing 100091,China Binzhou Medical College Yantai 264033,China.
- Publication Type:Meta-Analysis
- Keywords:
Chinese herbal injection;
network Meta-analysis;
unstable angina pectoris(UAP)
- MeSH:
Angina Pectoris;
Angina, Unstable/drug therapy*;
China;
Drugs, Chinese Herbal;
Humans;
Network Meta-Analysis;
Treatment Outcome
- From:
China Journal of Chinese Materia Medica
2021;46(13):3429-3445
- CountryChina
- Language:Chinese
-
Abstract:
The present study evaluated the curative efficacy of Chinese herbal injection on unstable angina pectoris( UAP) by network Meta-analysis. The databases,including Pub Med,Cochrane Library,Web of Science,CNKI,CBM,VIP and Wanfang were searched for randomized controlled trial( RCT) of Chinese herbal injection in the treatment of UAP. All researchers independently screened the articles,extracted the data and evaluated the quality. Open BUGS and Stata were employed for the analysis of the trials that met the quality standards. Fifty-eight studies were finally included in this study,involving 20 intervention measures. In terms of the effective rate,16 injections such as Dengzhan Xixin Injection,Xuesaitong Injection and Danshen Injection combined with western medicine exhibited significant efficacy. In terms of ECG,Puerarin Injection,Ginkgo Leaf Extract and Dipyridamole Injection( GDI),Breviscapine Injection combined with western medicine were superior to western medicine. In terms of the reduction of the angina attack times,Sodium Tanshinone ⅡASulfonate Injection,GDI and Dazhu Hongjingtian Injection combined with western medicine showed better effects than western medicine. In terms of shortening the angina duration,Shenmai Injection combined with western medicine was superior to western medicine. As revealed by the results,Dengzhan Xixin Injection,Xuesaitong Injection,Danshen Injection,Breviscapine Injection,Danshen Ligustrazine Injection combined with western medicine displayed prominent curative efficacy,which were recommended for clinical application. Meanwhile,appropriate intervention measures should be selected according to individual conditions. Limited by the quality of the included trials,the conclusions still need to be further verified.
