Erythrina alkaloids from stems of Erythrina corallodendron.
10.19540/j.cnki.cjcmm.20210331.201
- Author:
Yun-Shuang CAI
1
;
Yong LI
2
;
Zhao-Chan CHEN
1
;
Shi-Shan YU
3
Author Information
1. Guangxi University of Chinese Medicine Nanning 530200,China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050,China.
3. Guangxi University of Chinese Medicine Nanning 530200,China State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050,China.
- Publication Type:Journal Article
- Keywords:
Erythrina;
Erythrina alkaloids;
Erythrina corallodendron;
pharmacological activity
- MeSH:
Alkaloids;
Animals;
Chromatography, High Pressure Liquid;
Erythrina;
Magnetic Resonance Spectroscopy;
Mass Spectrometry;
Mice
- From:
China Journal of Chinese Materia Medica
2021;46(13):3368-3376
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to investigate Erythrina alkaloids from the stems of Erythrina corallodendron. Eighteen Erythrina alkaloids were isolated from the 95% ethanol extract of the stems of E. corallodendron by silica gel,octadecyl silica( ODS),Sephadex LH-20 column chromatography and preparative HPLC. With nuclear magnetic resonance( NMR) spectroscopy and mass spectrometry( MS),their structures were identified as crstanine A( 1),erytharbine( 2),cristamine C( 3),( +)-erystramindine( 4),10,11-dioxoerythraline( 5),8-oxoerythraline( 6),8-oxo-11β-methoxyerythradine( 7),11-methoxyerythradine( 8),( ±)-11-epi-methoxyerythraline( 9),( +)-erythraline( 10),crystamidine( 11),8-oxoerythrinine( 12),( +)-11α-hydroxyerysotrine( 13),erythrinine( 14),erysodine( 15),erysotrine-N-oxide( 16),( +)-erythratidine( 17),erythratine( 18). Compounds 1-4,7,9,11,13,16 and 17 were isolated from E. corallodendron for the first time. Furthermore,the cytotoxic activities of these Erythrina alkaloids were screened by MTT assay. The results showed that all compounds had no obvious cytotoxic activity. The analgesic activities of compounds1,6 and 8 were evaluated using an acetic acid-induced writhing test in mice. The writhing inhibition rates of compounds 1,6 and 8 at20 mg·kg~(-1)( ip) were 69%,70% and 62%,respectively( P<0. 01),indicating they have significant analgesic activity.
