Advance in biosynthesis and metabolic regulation of ginkgolides.
10.19540/j.cnki.cjcmm.20210320.101
- Author:
Jin-Fa DU
1
;
Ping LI
1
;
Xu LU
1
Author Information
1. State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University Nanjing 210009,China.
- Publication Type:Journal Article
- Keywords:
biosynthetic pathway;
ginkgolides;
metabolic engineering;
metabolism regulation;
synthetic biology
- MeSH:
Ginkgo biloba/genetics*;
Ginkgolides;
Humans;
Lactones;
Plant Extracts;
Terpenes
- From:
China Journal of Chinese Materia Medica
2021;46(13):3288-3297
- CountryChina
- Language:Chinese
-
Abstract:
Ginkgolides,the unique terpenoids in Ginkgo biloba,have a significant effect on the prevention and treatment of cardiovascular and cerebrovascular diseases. Metabolic regulation and synthetic biology strategies are efficient methods to obtain high-quality ginkgolides. The present study reviewed the cloning and functions of genes related to the biosynthetic pathway of ginkgolides,as well as relevant studies of omics,genetic transformation,and metabolic regulation in recent years,and predicted the research trends and prospects,aiming to provide a reference for discovering the key genes related to the biosynthetic pathway and the biosynthesis of ginkgolides.
