Research advance in multi-component pharmacokinetics of Chinese herbal extracts in recent five years.
10.19540/j.cnki.cjcmm.20210310.601
- Author:
Lu-Jing CAO
1
;
Shu-Yu ZHAN
1
;
Xiang-Yu JI
1
;
Bo-Hong ZHENG
1
;
Chun-Ying YE
1
;
Zi-Yi CHEN
1
;
Guo-Qiang LIU
1
;
Bao-Yue DING
1
Author Information
1. College of Medicine,Jiaxing University Jiaxing 314001,China.
- Publication Type:Review
- Keywords:
Chinese herbal extracts;
Chinese herbal medicine processing;
analysis technology;
complex system;
pathological state;
pharmacokinetics
- MeSH:
China;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional;
Quality Control
- From:
China Journal of Chinese Materia Medica
2021;46(13):3270-3287
- CountryChina
- Language:Chinese
-
Abstract:
The multi-component pharmacokinetic study of Chinese herbal extracts elaborates the in vivo processes,including absorption,distribution,metabolism,and excretion,of multiple bioactive components,which is of significance in revealing pharmacodynamic material basis of Chinese herbal medicine. In recent years,with the innovation in ideas,and development of techniques and methods on traditional Chinese medicine( TCM) research,the pharmacokinetic studies of Chinese herbal extracts were extensively performed,and notable progress has been made. This paper reviewed the advancement of multi-component pharmacokinetics of Chinese herbal extracts in recent five years from analysis technology of biological sample,the pharmacokinetic characteristics of Chinese herbal medicine with complex system,and the impacts of processing and pathological state on pharmacokinetics of Chinese herbal extracts,aiming to provide a reference for quality control,product development and rational medication of Chinese herbal extracts.
