Mechanisms and application of triptolide against breast cancer.
10.19540/j.cnki.cjcmm.20210225.601
- Author:
Jia-Xin LI
1
;
Jin-Feng SHI
1
;
Yi-Han WU
1
;
Hai-Ting XU
1
;
Chao-Mei FU
1
;
Jin-Ming ZHANG
1
Author Information
1. School of Pharmacy,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
- Publication Type:Review
- Keywords:
application;
breast cancer;
mechanism;
triptolide(TP)
- MeSH:
Breast Neoplasms/genetics*;
Diterpenes/pharmacology*;
Epoxy Compounds;
Female;
Humans;
Phenanthrenes;
Tumor Microenvironment
- From:
China Journal of Chinese Materia Medica
2021;46(13):3249-3256
- CountryChina
- Language:Chinese
-
Abstract:
Overtaking lung cancer,breast cancer is now the most commonly diagnosed cancer seriously threatening people's health and life. As the main effective component of Tripterygium wilfordii,triptolide( TP) has attracted increasing attention due to its multitarget and multi-pathway anti-tumor activity. Recent studies have revealed that breast cancer-sensitive TP enables the inactivation of breast cancer cells by inducing tumor cell apoptosis and autophagy,interfering in tumor cell metastasis,resisting drug resistance,arresting tumor cell cycle,and influencing tumor microenvironment. It has been recognized as a promising clinical antitumor agent by virtue of its widely accepted therapeutic efficacy. This paper reviewed the anti-breast cancer action and its molecular mechanisms of TP on the basis of the relevant literature in the past ten years,and proposed application strategies in view of the inadequacy of TP to provide a reference for further research on the application of TP in the treatment of breast cancer.
