Advances of Akkermansia muciniphila in regulating host functions.
10.19540/j.cnki.cjcmm.20210119.601
- Author:
Wen-Yu MA
1
;
Shi-Xiu FENG
2
;
Nai-Hong CHEN
3
Author Information
1. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine Guangzhou 510405, China.
2. Key Laboratory of Southern Subtropical Plant Diversity, Fairy Lake Botanical Garden, Shenzhen & Chinese Academy of Sciences Shenzhen 518004, China.
3. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine Guangzhou 510405, China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.
- Publication Type:Review
- Keywords:
Akkermansia muciniphila;
intestinal flora;
probiotics;
traditional Chinese medicine
- MeSH:
Akkermansia;
Humans;
Inflammatory Bowel Diseases;
Intestines;
Probiotics;
Verrucomicrobia/genetics*
- From:
China Journal of Chinese Materia Medica
2021;46(11):2760-2765
- CountryChina
- Language:Chinese
-
Abstract:
Akkermansia muciniphila, abbreviated as AKK and found in 2004, is an oval-shaped gram-negative bacterium isolated from a human feal. A. muciniphila is widely present in the intestinal tract of human. Its specialization in mucin degradation makes it a key organism at the mucosal interface between the lumen and host cells. More and more studies have shown that it can play the role of probiotics. Notably, declined levels of A. muciniphila have been observed in patients with diabetes, liver disease, cardiovascular disease, inflammatory bowel disease, neurodegenerative diseases, etc. In addition, A. muciniphila combined with traditional Chinese medicine, exhibited higher effect on regulating host functions, but the underlying mechanism was still unclear, requiring further in-depth research. Therefore, the aims of this review are to summarize the main effects of A. muciniphila on host health and its relationship with traditional Chinese medicine, summarize the main problems, and provide a reference for the further research of A. muciniphila and traditional Chinese medicine.
