Identification of quality markers of Qixuehe Capsules based on analytic hierarchy process and entropy weight methods.
10.19540/j.cnki.cjcmm.20210129.301
- Author:
Yu-Xi HUANG
1
;
Yan-Yan CHEN
1
;
Shi-Jun YUE
1
;
Li-Mei FENG
1
;
Ding-Qiao XU
1
;
Rui-Jia FU
1
;
Li-Ming XING
1
;
Bao-An WANG
2
;
Yu-Ping TANG
1
Author Information
1. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Compatibility,Shaanxi University of Chinese Medicine Xi'an 712046,China.
2. Shaanxi Momentum Qixuehe Pharmaceutical Co.,Ltd. Xi'an 712000,China.
- Publication Type:Journal Article
- Keywords:
Q-marker;
Qixuehe Capsules;
compatibility;
multi-effect;
quantitative identification
- MeSH:
Analytic Hierarchy Process;
Capsules;
Drugs, Chinese Herbal;
Entropy;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2021;46(11):2710-2717
- CountryChina
- Language:Chinese
-
Abstract:
Qixuehe Capsules is a compound Chinese patent medicine developed for treating the disorder of Qi and blood(a common etiology of gynecological disease), which has remarkable effects on smoothing liver and regulating Qi, activating blood circulation, and relieving pain. However, due to its complex prescriptions(15 herbs) and multiple effects, the quality control of Qixuehe Capsules has always been a bottleneck problem limiting its sustainable development. Therefore, this study adopted the traditional Chinese medicine Q-markers quantitative identification system established previously by our research group based on the combination of analytic hierarchy process and entropy weight methods. With the different effects of Qixuehe Capsules as the entry point, the comprehensive scores of chemical ingre-dients in Qixuehe Capsules under the items of effectiveness(smoothing liver and regulating qi, activating blood circulation, and relieving pain), testability and specificity were calculated and integrated, respectively. Subsequently, through the analysis of compatibility relationship of Qixuehe Capsules, 15 active ingredients with high comprehensive scores were found to be the top Q-mar-kers of Qixuehe Capsules, including ferulic acid, quercetin, caffeic acid, kaempferol, rutin, Z-ligustilide, senkyunolide Ⅰ, vanillic acid, protocatechuic acid, chlorogenic acid, rosmarinic acid, senkyunolide A, gallic acid, tetrahydropalmatine and eugenol. Collectively, this study not only provided scientific evidence for further research on the improvement and standardization of quality standards of Qixuehe Capsules but also provided methodological references for the quantitative identification of Q-markers of multi-effect traditional Chinese medicine formulae.
