Research Progress of Discoidin Domain Receptor 1 in Breast Cancer and Other Malignant Tumors.
10.3881/j.issn.1000-503X.13315
- Author:
Li CHEN
1
;
Meng-Liu ZHU
1
;
Xiang-Yi KONG
1
;
Xiang-Yu WANG
1
;
Zhong-Zhao WANG
1
;
Yi FANG
1
;
Jing WANG
1
Author Information
1. Department of Breast Surgical Oncology,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,CAMS and PUMC,Beijing 100021,China.
- Publication Type:Review
- Keywords:
breast cancer;
discoidin domain receptor 1;
receptor tyrosine kinase;
signaling pathway;
tumor
- MeSH:
Breast Neoplasms/genetics*;
Cell Adhesion;
Discoidin Domain Receptor 1;
Female;
Fibrosis;
Humans;
Receptor Protein-Tyrosine Kinases/genetics*
- From:
Acta Academiae Medicinae Sinicae
2021;43(4):634-641
- CountryChina
- Language:Chinese
-
Abstract:
Discoidin domain receptor 1(DDR1)is a critical member of the receptor tyrosine kinase family.It may be related to tumor invasion and metastasis,and the abnormal activation of DDR1 can lead to the occurrence and development of malignant tumors,inflammation,and fibrosis.DDR1 are involved in cell adhesion,migration,proliferation,secretion of cytokines,and remodeling of extracellular matrix,thus playing a critical role in various pathophysiological processes of the human body.In this review,we demonstrate the research progress of DDR1 in breast cancer and other malignant tumors,in order to provide a new theoretical basis for the prevention and treatment of breast cancer and other tumors.
