Expression and Significance of Leucine-rich Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with Acute Lymphoblastic Leukemia.
10.3881/j.issn.1000-503X.13645
- Author:
Xuan LI
1
;
Wen-Peng WANG
1
;
Min ZHOU
1
;
Xiao-Rui XU
1
;
Ji-Zhao GAO
1
Author Information
1. Department of Pediatrics,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China.
- Publication Type:Journal Article
- Keywords:
Wnt pathway;
acute lymphoblastic leukemia;
leucine-rich repeat-containing G-protein coupled receptor
- MeSH:
Child;
Humans;
Leucine;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
RNA, Messenger/genetics*;
Receptors, G-Protein-Coupled/genetics*;
Wnt Signaling Pathway
- From:
Acta Academiae Medicinae Sinicae
2021;43(4):595-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of leucine-rich repeat-containing G-protein coupled receptor(LGR)5/6 in childhood acute lymphoblastic leukemia(ALL). Methods A total of 39 children who had ALL and achieved complete remission on day 33 after induction therapy were enrolled.The children before induction therapy were considered as the incipient group,and those who achieved complete remission on day 33 by induction therapy were considered as the remission group.According to the degree of risk,they were assigned into 3 groups:low-risk(
