Prognosis and Related Factors of Patients with Pathological Complete Response after Neoadjuvant Therapy for Gastric Cancer.
- Author:
Tong-Bo WANG
1
;
Hong ZHOU
1
;
Xiao-Jie ZHANG
1
;
Chong-Yuan SUN
1
;
Chun-Guang GUO
1
;
Ying-Tai CHEN
1
;
Ai-Ping ZHOU
1
;
Jing JIN
1
;
Dong-Bing ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: locally advanced gastric cancer; neoadjuvant therapy; pathological complete response; prognosis; radical gastrectomy
- MeSH: Humans; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Retrospective Studies; Stomach Neoplasms/pathology*
- From: Acta Academiae Medicinae Sinicae 2021;43(4):571-578
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the related factors of pathological complete response(pCR)of patients with gastric cancer treated by neoadjuvant therapy and resection,and to analyze the risk factors of prognosis. Methods The clinical and pathological data of 490 patients with gastric cancer who received neoadjuvant therapy followed by radical gastrectomy from January to December in 2008 were retrospectively analyzed.Univariate and multivariate analyses were performed to identify the risk factors affecting pCR and prognosis. Results Among the 490 patients,41 achieved pCR,and the overall pCR rate was 8.3%(41/490).The pCR rate was 16.0% in the neoadjuvant chemoradiation group and 6.4% in the neoadjuvant chemotherapy group.The results of multivariate analysis showed that neoadjuvant chemoradiation(
