Oral Mucosal Diffuse Large B-cell Lymphoma Caused by Long-term Oral Methotrexate:Report of One Case.
10.3881/j.issn.1000-503X.13717
- Author:
Yan-Quan LIU
1
;
Xiao-Mei HU
2
;
Yue YIN
3
;
Lang-Hui ZHANG
4
;
Hai-Ying FU
4
;
Ting-Bo LIU
4
;
Jian-Zhen SHEN
4
Author Information
1. First Clinical Medical College,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000,China.
2. Department of Pathology, Fujian Medical University Union Hospital,Fuzhou 350001,China.
3. Department of Cell Morphology, Fujian Medical University Union Hospital,Fuzhou 350001,China.
4. Department of Hematology, Fujian Medical University Union Hospital,Fuzhou 350001,China.
- Publication Type:Journal Article
- Keywords:
extranodal lymphoma;
immunosuppressive agents;
lymphoma;
methotrexate;
methotrexate-associated lymphoproliferative disorders;
other iatrogenic immunodeficiency-associated lymphoproliferative disorders
- MeSH:
Arthritis, Rheumatoid/drug therapy*;
Humans;
Lymphoma, Large B-Cell, Diffuse/drug therapy*;
Lymphoproliferative Disorders;
Methotrexate/adverse effects*
- From:
Acta Academiae Medicinae Sinicae
2021;43(3):488-493
- CountryChina
- Language:Chinese
-
Abstract:
A case of primary oral mucosal diffuse large B-cell lymphoma(DLBCL)due to long-term use of methotrexate(MTX)for the treatment of rheumatoid arthritis(RA)was admitted to the Department of Hematology,Fujian Medical University Union Hospital.We analyzed and discussed the clinical features,diagnosis and treatment,and prognosis of specific malignant lymphoma induced by MTX in this RA patient.Our purpose is to improve the awareness and knowledge of other iatrogenic immunodeficiency-associated lymphoproliferative disorders of clinicians and pathologists.This study provides a new reference for the clinical diagnosis and treatment of MTX-associated DLBCL.
