Research Progress of FAM60A in the Regulation of Cellular Function.
10.3881/j.issn.1000-503X.13430
- Author:
Yong-Hong SUN
1
;
Xiao-Wei SUN
2
;
Lin YANG
3
;
Bo CHENG
2
;
Yong-Lin CHEN
3
Author Information
1. The First School of Clinical Medicine, the First Hospital,Lanzhou University,Lanzhou 730000,China.
2. School of Life Sciences, the First Hospital,Lanzhou University,Lanzhou 730000,China.
3. Department of Pathology,the First Hospital,Lanzhou University,Lanzhou 730000,China.
- Publication Type:Journal Article
- Keywords:
FAM60A;
SIN3 transcription regulator family member A/histone deacetylase complex;
regulatory effect;
tumor
- MeSH:
Cell Cycle Proteins;
Cell Differentiation;
Cell Proliferation;
DNA-Binding Proteins;
Humans;
Sin3 Histone Deacetylase and Corepressor Complex
- From:
Acta Academiae Medicinae Sinicae
2021;43(3):469-474
- CountryChina
- Language:Chinese
-
Abstract:
FAM60A,a cell cycle protein,is a subunit of the SIN3 transcription regulator family member A/histone deacetylase(SIN3-HDAC)complex and plays an important role in cell cycle regulation,cell morphology change,cell proliferation,differentiation and migration,early embryogenesis and so on.Studies in recent years have shown that FAM60A plays a role in the occurrence and development of tumors including human osteosarcoma,esophageal cancer,gastric cancer,lung cancer and liver cancer,providing a new research direction for tumor diagnosis and treatment.Based on the research results in recent years at home and abroad,this paper discussed the effects of FAM60A on cellular functions.
