Research Progress of Pharmacological Intervention of Sevoflurane-induced Nerve Injury in the Developing Brain.
10.3881/j.issn.1000-503X.12732
- Author:
Xiang-Kun ZHAO
1
;
Yi TIAN
1
Author Information
1. Department of Anesthesiology,Haikou People's Hospital/Haikou Hospital Affiliated to Xiangya School of Medicine,Central South University,Haikou 570208,China.
- Publication Type:Review
- Keywords:
inflammation;
neurotoxicity;
pharmacological intervention;
sevoflurane
- MeSH:
Anesthetics, Inhalation/adverse effects*;
Animals;
Apoptosis;
Brain;
Child;
Female;
Humans;
Methyl Ethers;
Neuroprotective Agents/therapeutic use*;
Oxidative Stress;
Pregnancy;
Sevoflurane
- From:
Acta Academiae Medicinae Sinicae
2021;43(3):462-468
- CountryChina
- Language:Chinese
-
Abstract:
Sevoflurane is one of the most commonly used inhaled anesthetics in obstetric and pediatric general anesthesia.According to related literature,this article reviews major possible mechanisms including myelin formation damage,nerve inflammation,cell apoptosis,oxidative stress,inhibition of histone acetylation,synapsis and receptor changes of sevoflurane-induced neurotoxicity in animal experiments.Furthermore,we summarize the neuroprotection effects and functioning mechanisms of anti-anemia medicine,plant-based drugs,alpha 2 adrenoceptor agonists and others,aiming to provide a basis for the brain protection of fetuses and infants during the perioperative period.
