Roles of Myeloid-derived Suppressor Cells in Breast Cancer Metastasis.
10.3881/j.issn.1000-503X.12586
- Author:
Xin-Yi PENG
1
;
Yan LI
2
;
Zhi-Li XU
1
;
Yong GUO
2
Author Information
1. The First Clinical College of Zhejiang Chinese Medical University,Hangzhou 310053,China.
2. Department of Oncology,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China.
- Publication Type:Review
- Keywords:
breast cancer;
metastasis;
myeloid-derived suppressor cells;
tumor microenvironment
- MeSH:
Breast Neoplasms;
Female;
Humans;
Lung Neoplasms;
Myeloid-Derived Suppressor Cells;
Neoplasm Metastasis;
Tumor Microenvironment
- From:
Acta Academiae Medicinae Sinicae
2021;43(3):445-451
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer patients with bone,liver and lung metastases tend to have a poor prognosis.According to Paget's "seed and soil" theory,metastatic cancer cell "seeds" must fall on congenial target organ "soil".Studies have shown that myeloid-derived suppressor cells(MDSCs)can be recruited at the site of breast cancer metastasis in advance and play a role in the metastasis of breast cancer cells.This paper reviews the biological characteristics of MDSCs,the roles of MDSCs in peripheral circulation,prometastatic niche,and metastatic site during breast cancer metastasis,as well as the research progress of MDSCs-targeted treatment of breast cancer metastasis.
