Interactions between cells and biomaterials in tissue engineering: a review.

Author: Jiasheng ZHANG ¹ ; Gang WU ² ; Jiang QIU ¹
Author Information

1. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, Guangdong, China.
2. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510000, Guangdong, China.
Publication Type:Review
Keywords: extra cellular matrix; growth factor; integrin; mechanotransduction; stem cell; surface modification
MeSH: Biocompatible Materials; Cell Adhesion; Cell Differentiation; Extracellular Matrix; Tissue Engineering
From: Chinese Journal of Biotechnology 2021;37(8):2668-2677
CountryChina
Language:Chinese
Abstract: Seed cells, biomaterials and growth factors are three important aspects in tissue engineering. Biomaterials mimic extra cellular matrix in vivo, providing a sound environment for cells to grow and attach, so as to maintain cell viability and function. The physicochemical properties and modification molecules of material surface mediate cell behaviors like cell adhesion, proliferation, migration and differentiation, which in turn affect cellular function and tissue regeneration efficacy. Furthermore, the modification molecules of material surface are the direct contact point for cell adhesion and growth. Therefore, the interactions between cells and surface modification molecules are the key to tissue engineering. This review summarizes the effects of surface modification molecules on cell phenotypes and functions.