Advances of Angiopoietin-Tie axis in vascular and lymphatic system-related diseases.

Rui Wang; Meijuan Huang; Yanyan XU; Cai Yuan; Mingdong Huang; Longguang Jiang

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Advances of Angiopoietin-Tie axis in vascular and lymphatic system-related diseases.

Author: Rui WANG ¹ ; Meijuan HUANG ² ; Yanyan XU ³ ; Cai YUAN ³ ; Mingdong HUANG ¹ ; Longguang JIANG ¹
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1. College of Chemistry, Fuzhou University, Fuzhou 350116, Fujian, China.
2. Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.
3. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, Fujian, China.
Publication Type:Review
Keywords: Angiopoietin1; Angiopoietin2; Tie1; Tie2; lymphatic system; vascular endothelial cell
MeSH: Angiopoietins; Endothelial Cells/metabolism*; Humans; Lymphatic Diseases; Lymphatic System/metabolism*; Receptor, TIE-2/metabolism*; Signal Transduction; Vascular Endothelial Growth Factor A
From: Chinese Journal of Biotechnology 2021;37(8):2633-2644
CountryChina
Language:Chinese
Abstract: Endothelial cells that form the inner layers of both blood and lymphatic vessels are important components of the vascular system and are involved in the pathogenesis of vascular and lymphatic diseases. Angiopoietin (Ang)-Tie axis in endothelial cells is the second endothelium-specific ligand-receptor signaling system necessary for embryonic cardiovascular and lymphatic development in addition to the vascular endothelial growth factor receptor pathway. The Ang-Tie axis also maintains vascular homeostasis by regulating postnatal angiogenesis, vessel remodeling, vascular permeability, and inflammation. Therefore, the dysfunction of this system leads to many vascular and lymphatic diseases. In light of the recent advances on the role of the Ang-Tie axis in vascular and lymphatic system-related diseases, this review summarizes the functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, ocular angiogenesis, shear stress response, atherosclerosis, tumor angiogenesis, and metastasis. Moreover, this review summarizes the relevant therapeutic antibodies, recombinant proteins, and small molecular drugs associated with the Ang-Tie axis.