- Author:
Jiahui SUN
1
;
Peiling GENG
2
;
Xiaofu WAN
1
;
Zhiming YUAN
1
;
Hairong XIONG
2
;
Xiaomin HU
2
Author Information
- Publication Type:Review
- Keywords: adsorption; phage; phage escape mechanism; phage-host interaction; receptor binding proteins (RBPs)
- MeSH: Bacteria; Bacteriophage Receptors; Bacteriophages/genetics*; Carrier Proteins; Protein Binding
- From: Chinese Journal of Biotechnology 2021;37(8):2614-2622
- CountryChina
- Language:Chinese
- Abstract: Bacteriophages bind to the bacteria receptor through the receptor binding proteins (RBPs), a process that requires the involvement of complex atomic structures and conformational changes. In response to bacteriophage infection, bacteria have developed a variety of resistance mechanisms, while bacteriophages have also evolved multiple antagonistic mechanisms to escape host resistance. The exploration of the "adsorption-anti adsorption-escape process" between bacteriophages and bacteria helps us better understand the co-evolution process of bacteriophages and bacteria, which is important for the development of phage therapeutic technologies and phage-based biotechnologies. This review summarizes the bacteriophage adsorption related proteins, how bacteriophages escape host resistance based on the RBP alternations, and the recent progress of RBP-related biotechnologies.