Immunization against porcine epidemic diarrhea virus and vaccine development.

Shijuan Dong; Chunfang Xie; Fusheng SI; Bingqing Chen; Ruisong YU; Zhen LI

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Immunization against porcine epidemic diarrhea virus and vaccine development.

Author: Shijuan DONG ¹ ; Chunfang XIE ¹ ; Fusheng SI ¹ ; Bingqing CHEN ¹ ; Ruisong YU ¹ ; Zhen LI ¹
Author Information

1. Shanghai Key Laboratory of Agricultural Genetics and Breeding, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China.
Publication Type:Review
Keywords: coronavirus; gut-mammary gland-sIgA axis; immunization; porcine epidemic diarrhea virus; vaccine
MeSH: Animals; Antibodies, Viral; Coronavirus Infections/veterinary*; Female; Immunization; Porcine epidemic diarrhea virus; Pregnancy; Swine; Swine Diseases/prevention & control*; Viral Vaccines
From: Chinese Journal of Biotechnology 2021;37(8):2603-2613
CountryChina
Language:Chinese
Abstract: Porcine epidemic diarrhea (PED) is a major disease of pigs that inflicts heavy losses on the global pig industry. The etiologic agent is the porcine epidemic diarrhea virus (PEDV), which is assigned to the genus Alphacoronavirus in the family Coronaviridae. This review consists of five parts, the first of which provides a brief introduction to PEDV and its epidemiology. Part two outlines the passive immunity in new born piglets and the important role of colostrum, while the third part summarizes the characteristics of the immune systems of pregnant sows, discusses the concept of the "gut-mammary gland-secretory IgA(sIgA) axis" and the possible underpinning mechanisms, and proposes issues to be addressed when designing a PEDV live vaccine. The final two parts summarizes the advances in the R&D of PEDV vaccines and prospects future perspectives on prevention and control of PEDV, respectively.