The role of nuclear receptor transcription factor NR2F6 in tumor.

Ling Huang; Jiahui Liu; Yi Zhu; Quan Zhou; Bin Xiao; Zhaohui Sun; Linhai LI

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The role of nuclear receptor transcription factor NR2F6 in tumor.

Author: Ling HUANG ¹ ; Jiahui LIU ¹ ; Yi ZHU ¹ ; Quan ZHOU ¹ ; Bin XIAO ¹ ; Zhaohui SUN ¹ ; Linhai LI ¹
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1. Department of Laboratory Medicine, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, China.
Publication Type:Review
Keywords: NR2F6; chemotherapy resistance; immune checkpoint; orphan nuclear receptors; transcription factor
MeSH: Gene Expression Regulation; Humans; Neoplasms/genetics*; Receptors, Cytoplasmic and Nuclear/genetics*; Repressor Proteins/genetics*; Transcription Factors/genetics*
From: Chinese Journal of Biotechnology 2021;37(8):2595-2602
CountryChina
Language:Chinese
Abstract: Nuclear receptor subfamily 2, group F, member 6 (NR2F6) is a member of orphan nuclear receptors, which is expressed in major tissues and organs of the human body, and plays an important role in the regulation of various biological functions and gene expressions. Recent studies have shown that the expression of NR2F6 was up-regulated in a variety of malignant tumors and showed significant correlations with cancer progression. These findings triggered the widespread interest in understanding the relationship between NR2F6 and cancer development and progression. In addition, the latest studies have underscored that NR2F6 was involved in enhancing antitumor immune responses that could serve as a potential target for immune regulation. This review summarizes the biological functions of NR2F6 and its role in tumors, with the aim to provide new insights into effective cancer therapies.