Evaluation of drug myocardial toxicity and biological activity by real time xCELLigence analysis: a review.
- Author:
Xu ZHANG
1
;
Ruiying WANG
2
;
Rongchang CHEN
2
;
Lijiao XU
1
;
Xiaobo SUN
2
;
Miao YU
1
;
Guibo SUN
2
Author Information
- Publication Type:Review
- Keywords: RTCA; biological activity; cell detection; drug research; myocardial toxicity
- MeSH: Pharmaceutical Preparations
- From: Chinese Journal of Biotechnology 2021;37(7):2425-2434
- CountryChina
- Language:Chinese
- Abstract: Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.