Ligands of TetR family transcriptional regulators: a review.
- Author:
Panpan WU
1
;
Bowen LI
1
;
Ketao CHEN
1
;
Hang WU
1
;
Buchang ZHANG
1
Author Information
- Publication Type:Review
- Keywords: TetR family transcription factors; archaea; bacteria; feed-forward control; feedback regulation; ligand
- MeSH: Anti-Bacterial Agents; Bacteria/metabolism*; Bacterial Proteins/metabolism*; Gene Expression Regulation, Bacterial; Ligands; Quorum Sensing
- From: Chinese Journal of Biotechnology 2021;37(7):2379-2392
- CountryChina
- Language:Chinese
- Abstract: TetR family transcriptional regulators (TFRs) are widely distributed in bacteria and archaea, and the first discovered TFR was confirmed to control the expression of tetracycline efflux pump in Escherichia coli. TFRs can bind DNAs and ligands. Small molecule ligands can induce conformational changes of TFRs, inhibiting or promoting TFRs to control target gene expression. Currently, TFRs have a wide variety of ligands, including carbohydrates, proteins, fatty acids and their derivatives, metal ions, and so on. Due to the diversity of ligands, TFRs regulate a wide range of physiological processes, from basic carbon metabolism and nitrogen metabolism to quorum sensing and antibiotic biosynthesis. On the basis of the recent studies in our laboratory and the literature, we review here the regulatory mechanism mediated by ligands of TFRs in primary and secondary metabolism, as well as the application of ligands for TFRs in the development of gene route and the activation of antibiotic biosynthesis.
