Enzyme-based targeted disintegration of biofilms formed by food-borne pathogens: a review.

Author: Qian WU ¹ ; Zhaohuan ZHANG ¹ ; Jinrong TONG ¹ ; Zhenhua HUANG ¹ ; Jing LIU ¹ ; Haiquan LIU ¹ ; Yingjie PAN ¹ ; Yong ZHAO ¹
Author Information

1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Publication Type:Review
Keywords: biofilm; enzymes; foodborne pathogens; targeted disintegration
MeSH: Biofilms; Humans; Quorum Sensing
From: Chinese Journal of Biotechnology 2021;37(7):2366-2378
CountryChina
Language:Chinese
Abstract: Food-borne pathogens pose great risks to human health and public safety, and the formation of biofilm exacerbates their pathogenicity and antimicrobial resistance. Enzymes can target special substances in the biofilm to disintegrate the biofilm of food-borne pathogens, which has great potential for applications. This review summarized the progress of using enzymes to disintegrate the biofilms of food-borne pathogens, highlighting quorum-quenching enzymes, C-di-GMP metabolic enzymes, as well as extracellular matrix hydrolases. Finally, challenges and perspectives on developing enzymes into effective products for disintegrating the biofilms of food-borne pathogens were discussed.