Long non-coding RNA regulates bone metabolism via Wnt/β-catenin signaling pathway.
- Author:
Yu YUAN
1
;
Lingli ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Wnt; bone metabolism; lncRNA; β-catenin
- MeSH: Cell Line, Tumor; Cell Proliferation; MicroRNAs; RNA, Long Noncoding/genetics*; Wnt Signaling Pathway/genetics*
- From: Chinese Journal of Biotechnology 2021;37(7):2342-2350
- CountryChina
- Language:Chinese
- Abstract: The balance of bone metabolism depends on the dynamic balance between bone formation and bone resorption. Wnt/β-catenin signaling pathway is involved in the regulation of bone resorption and bone formation, and plays an important role in maintaining the balance of bone metabolism. Recently, long non-coding RNA (lncRNA) is shown to play an essential role in different process of bone metabolism. LncRNA can also regulate the balance of bone metabolism via Wnt/β-catenin signaling pathway. Few studies report that lncRNA regulates bone metabolism via Wnt/β-catenin signaling pathway. Therefore, we summarize here the role of lncRNA in bone metabolism from the perspective of Wnt/β-catenin signaling pathway. LncRNA indirectly regulates Wnt/β-catenin signaling pathway by targeting miRNAs as well as activating or inhibiting Wnt/β-catenin signaling pathway via targeting the key molecules of Wnt/β-catenin signaling pathway, thus to regulate bone metabolism. These findings provide new ideas and directions for the study of the mechanism whereby lncRNA regulates bone metabolism.
