Application of supramolecular peptide self-assembly in biomedicine.

Author: Weikang YU ¹ ; Shanshan ZHANG ¹ ; Zhanyi YANG ¹ ; Jiajun WANG ¹ ; Anshan SHAN ¹
Author Information

1. Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, Heilongjiang, China.
Publication Type:Journal Article
Keywords: antimicrobial peptides; fibrous peptide hydrogels; influencing factors; molecular mechanisms; self-assembled peptides
MeSH: Drug Delivery Systems; Hydrogels; Peptides; Tissue Engineering
From: Chinese Journal of Biotechnology 2021;37(7):2240-2255
CountryChina
Language:Chinese
Abstract: In recent years, peptide self-assembly has received much attention because of its ability to form regular and ordered structures with diverse functions. Self-assembled peptides can form aggregates with defined structures under specific conditions. They show different characteristics and advantages (e.g., good biocompatibility and high stability) compared with monomeric peptides, which form the basis for potential application in the fields of drug delivery, tissue engineering, and antiseptics. In this paper, the molecular mechanisms, types and influencing factors of forming self-assembled peptides were reviewed, followed by introducing the latest advances on fibrous peptide hydrogels and self-assembled antimicrobial peptides. Furthermore, the challenges and perspectives for peptide self-assembly technology were discussed.