Complex structures and diverse functions of nuclear bodies: a review.

Author: Xinyuan LIU ¹ ; Lian-Feng LI ¹ ; Hua-Ji QIU ¹
Author Information

1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, Heilongjiang, China.
Publication Type:Review
Keywords: antiviral response; assembly; function; nuclear bodies
MeSH: Animals; Cell Nucleus; Epigenesis, Genetic; Intranuclear Inclusion Bodies/metabolism*; Nuclear Proteins/metabolism*
From: Chinese Journal of Biotechnology 2021;37(7):2223-2231
CountryChina
Language:Chinese
Abstract: Nuclear bodies are membrane-free nuclear substructures that are localized in the mammalian nuclear matrix region. They are multiprotein complexes that recruit other proteins to participate in various cellular activities, such as transcription, RNA splicing, epigenetic regulation, tumorigenesis and antiviral defense. It is of great significance to clarify the functions and regulatory mechanisms of nuclear bodies to probe related diseases and virus-host interactions. This review takes several nuclear bodies associated proteins as examples, summarizes the formation process, structure and functions of nuclear bodies, and focuses on their important roles in antiviral infection. It is expected to provide new insight into host antiviral mechanisms.