Improvement of natural product production in Streptomyces by manipulating pathway-specific regulators.

Author: Wan XIONG ¹ ; Yanwen DUAN ¹ ; Xiaohui YAN ¹ ; Yong HUANG ¹
Author Information

1. Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, Hunan, China.
Publication Type:Review
Keywords: Streptomyces; nature products; regulators; titer improvement
MeSH: Biological Products; Multigene Family; Secondary Metabolism; Streptomyces/genetics*
From: Chinese Journal of Biotechnology 2021;37(6):2127-2146
CountryChina
Language:Chinese
Abstract: Streptomyces are major sources of bioactive natural products. Genome sequencing reveals that Streptomyces have great biosynthetic potential, with an average of 20-40 biosynthetic gene clusters each strain. However, most natural products from Streptomyces are produced in low yields under regular laboratory cultivation conditions, which hamper their further study and drug development. The production of natural products in Streptomyces is controlled by the intricate regulation mechanisms. Manipulation of the regulatory systems that govern secondary metabolite production will strongly facilitate the discovery and development of natural products of Streptomyces origin. In this review, we summarize progresses in pathway-specific regulators from Streptomyces in the last five years and highlight their role in improving the yields of corresponding natural products.