Advances in biosynthesis of cadinane sesquiterpenes.

Longyu Jiang; Yanhua Wen; Yu Peng; Tianjiao Chen; Jingjing Chen; Jinling Yang; Ting Gong; Ping Zhu

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Advances in biosynthesis of cadinane sesquiterpenes.

Author: Longyu JIANG ¹ ; Yanhua WEN ¹ ; Yu PENG ¹ ; Tianjiao CHEN ¹ ; Jingjing CHEN ¹ ; Jinling YANG ¹ ; Ting GONG ¹ ; Ping ZHU ¹
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1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Key Laboratory of Biosynthesis of Natural Products of the National Health Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Publication Type:Journal Article
Keywords: biosynthesis; cadinane sesquiterpenes; pharmacological activities; sesquiterpene synthase; structure type
MeSH: Anti-Inflammatory Agents; Polycyclic Sesquiterpenes; Sesquiterpenes
From: Chinese Journal of Biotechnology 2021;37(6):1952-1967
CountryChina
Language:Chinese
Abstract: Cadinanes are a class of bicyclic sesquiterpenes with complex stereochemistry and broad pharmacological activities, such as antibacterial, anti-inflammatory, and hypoglycemic activities. To date, structurally diverse and bioactive cadinane sesquiterpenes have been isolated and identified from a variety of plants and microorganisms. Moreover, deeper understandings on cadinane sesquiterpene synthases have been made. This article categorized the 124 new cadinanes which were published in the literatures in the past four years (2017-2020) into five structural types, and presented their pharmacological activities. We also illustrated the elucidation of the biosynthetic pathways for typical cadinanes, summarized the research progress on cadinane sesquiterpene synthases. Finally, current challenges and future prospects were proposed and discussed.