Application of methyltransferases in microbial synthesis of natural products.
- Author:
Xiangyan ZHANG
1
;
Xiaolin SHEN
1
;
Xinxiao SUN
1
;
Jia WANG
1
;
Qipeng YUAN
1
Author Information
- Publication Type:Review
- Keywords: metabolic engineering; methyltransferases; natural products; synthetic biology
- MeSH: Biological Products; Methylation; Methyltransferases/metabolism*
- From: Chinese Journal of Biotechnology 2021;37(6):1869-1886
- CountryChina
- Language:Chinese
- Abstract: Methyltransferases (MTs) constitute a large group of enzymes that catalyze the transfer of a methyl moiety, most frequently from S-adenosyl-L-methionine, to their substrates. It plays an essential role in regulation of gene expression and synthesis of many natural compounds. Owing to its broad substrate spectrum, MTs make important contributions to diversify the spectrum of products through methylation modifications. Recently, great progress has been made in application of MTs for the biosynthesis of various natural products including phenylpropane compounds, fragrances, hormones and antibiotics, which is summarized in this review. Moreover, we highlighted the strategies of using MTs for efficient production and for expanding the diversity of these methylated natural products, and discussed the current challenges and future prospects in this area.
