Function, structure and catalytic mechanism of sucrose phosphate synthase: a review.

Author: Jiyong SU ¹ ; Yuan YAO ² ; Yuhan LIU ¹ ; Qiuyu HAN ¹ ; Wenlu ZHANG ¹
Author Information

1. Engineering Research Center of Glycoconjugates, Ministry of Education, School of Life Sciences, Northeast Normal University, Changchun 130024, Jilin, China.
2. Media Academy, Jilin Engineering Normal University, Changchun 130052, Jilin, China.
Publication Type:Review
Keywords: carbohydrate distribution in plant; catalytic mechanism; crystal structure; plant growth; sucrose phosphate synthase
MeSH: Carbohydrate Metabolism; Glucosyltransferases/metabolism*; Plants/metabolism*; Sucrose
From: Chinese Journal of Biotechnology 2021;37(6):1858-1868
CountryChina
Language:Chinese
Abstract: Sucrose is a natural product occurs widely in nature. In living organisms such as plants, sucrose phosphate synthase (SPS) is the key rate-limiting enzyme for sucrose synthesis. SPS catalyzes the synthesis of sucrose-6-phosphate, which is further hydrolyzed by sucrose phosphatase to form sucrose. Researches on SPS in recent decades have been focused on the determination of enzymatic activity of SPS, the identification of the inhibitors and activators of SPS, the covalent modification of SPS, the carbohydrate distribution in plants regulated by SPS, the mechanism for promoting plant growth by SPS, the sweetness of fruit controlled by SPS, and many others. A systematic review of these aspects as well as the crystal structure and catalytic mechanism of SPS are presented.