Progress in vitamin C biosynthesis related dehydrogenases.

Author: Yue CHEN ¹ ; Jingwen ZHOU ¹ ; Jian CHEN ¹
Author Information

1. National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: 2-keto-L-gulonic acid; dehydrogenase; gluconic acid; microbial fermentation; sorbose; vitamin C
MeSH: Ascorbic Acid/biosynthesis*; Fermentation; Gluconates; Oxidoreductases/metabolism*; Sorbose
From: Chinese Journal of Biotechnology 2021;37(6):1827-1844
CountryChina
Language:Chinese
Abstract: Vitamin C is an essential vitamin for human beings. It has a huge market in the fields of food and pharmaceuticals. 2-keto-L-gulonic acid is an important precursor to produce vitamin C by microbial fermentation in industrial. In microbial fermentations, the L-sorbose pathway and the D-gluconate pathway have been the focus of research because of high yield. This article aims at stating recent research progress in dehydrogenases related to biosynthesis of vitamin C in the L-sorbose pathway and the D-gluconate pathway. The properties of dehydrogenase in terms of localization, substrate specificity, cofactors, and electron transport carrier are elaborated. And then, the main problems and strategies are reviewed in the L-sorbose pathway and in the D-gluconate pathway. Finally, future research on the dehydrogenases in the biosynthesis of vitamin C through L-sorbose pathway and D-gluconate pathway is discussed.