Effect of piceatannol against malignant melanoma
- Author:
Bo YU
1
;
Wei LIU
1
;
Min-Qi HU
1
;
Xiu-Fa TANG
1
;
Chun-Jie LI
1
;
Lin QUE
1
Author Information
- Publication Type:Journal Article
- Keywords: malignant melanoma; piceatannol; spleen tyrosine kinase
- MeSH: Animals; Cell Line, Tumor; Cell Movement; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melanoma/drug therapy*; Mice; Neoplasm Invasiveness; Stilbenes/pharmacology*; Syk Kinase; Vascular Endothelial Growth Factor A
- From: West China Journal of Stomatology 2021;39(4):413-418
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the antitumor effect of piceatannol (PIC) on malignant melanoma
METHODS:B16F10 cells were cultured
RESULTS:The cell viability of B16F10 decreased with increasing PIC concentration. The results of the Transwell assay showed that invasion ability decreased with increasing PIC concentration, and healing time was prolonged at increased PIC concentration in the wound healing assay. Western blot results showed that PIC mainly inhibited the phosphorylation of Syk and inhibited the expression of MMP-2, MMP-9, and VEGF. RNA interference pointed out that blocking the expression of Syk can reveal the same inhibition effect on B16F10 cells as PIC.
CONCLUSIONS:PIC might block the progression of malignant melanoma by inhibiting spleen tyrosine kinase.
