Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus.

Nan Tang; Yu-yao Zhang; Jue-hua Cheng; Zhi-bai Zhao; Yuan Fan

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Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus.

Author: Nan TANG ¹ ; Yu-Yao ZHANG ¹ ; Jue-Hua CHENG ¹ ; Zhi-Bai ZHAO ¹ ; Yuan FAN ¹
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1. Dept. of Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Nanjing Medical University, Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing 210029, China.
Publication Type:Journal Article
Keywords: CC chemokine ligand 17; CC chemokine receptor 4; CXC chemokine ligand 10; CXC chemokine receptor 3; oral lichen planus
MeSH: Chemokine CCL17; Chemokine CXCL10; Humans; Lichen Planus, Oral; Ligands; Receptors, CCR4; Receptors, CXCR3
From: West China Journal of Stomatology 2021;39(4):405-412
CountryChina
Language:English
Abstract: OBJECTIVES:This study aimed to determine whether a correlation existed between CXC chemokine ligand 10 (CXCL10)-CXC chemokine receptor 3 (CXCR3) and CC chemokine ligand 17 (CCL17)-CC chemokine receptor 4 (CCR4) in the pathogenesis of oral lichen planus (OLP).
METHODS:Peripheral blood of OLP patients (non-erosive and erosive groups) and healthy controls were collected, and T cells were isolated and purified. T cells were co-cultured with three groups: blank, anti-CXCR3, and anti-CCR4. CXCR3 and CCR4 expression were detected by flow cytometry, and CXCL10 and CCL17 were detected by enzyme-linked immunosorbent assay, respectively.
RESULTS:The purities of T cells were all >95% in the three groups (
CONCLUSIONS:Two axes interact with each other in the pathogenesis of OLP and may play different roles in its occurrence and development.