Serum Ferritin and the Risk of Metabolic Syndrome: A Systematic Review and Dose-Response Meta-Analysis of Cross-sectional Studies.

Wei Chun Bai Zhang; Yang Xing; Bing Shao

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Serum Ferritin and the Risk of Metabolic Syndrome: A Systematic Review and Dose-Response Meta-Analysis of Cross-sectional Studies.

Author: Wei Chun Bai ZHANG ^{1
,

2} ; Yang XING ^{1
,

3} ; Bing SHAO ^{1
,

3
,

4}
Author Information

1. Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China
2. School of Public Health, Capital Medical University, Beijing 100069, China.
3. Beijing Research Center for Preventive Medicine, Beijing 100013, China.
4. School of Public Health, Capital Medical University, Beijing 100069, China
Publication Type:Systematic Review
Keywords: Dose-response relationship; Meta-analysis; Metabolic syndrome; Serum ferritin
MeSH: Biomarkers/blood*; Female; Ferritins/blood*; Humans; Male; Metabolic Syndrome/epidemiology*; Risk Factors; Sex Characteristics
From: Biomedical and Environmental Sciences 2021;34(8):623-631
CountryChina
Language:English
Abstract: Objective:This study aims to assess the dose-response relationship between serum ferritin (SF) and metabolic syndrome (MetS) in the two sexes.
Methods:We searched for articles on PubMed, the Cochrane Library, EMBASE, and the Web of Science databases that were published from 1950 to 2020. The summary odds ratio (
Results:This study included 14 studies and 74,710 samples. The results of the classical meta-analysis showed that SF was positively associated with MetS (
Conclusions:Our study shows that SF is significantly and positively associated with MetS, and the risk in the male population is higher than that in the female population. This finding also supports the recommendation of using SF as an early warning marker of MetS.