Current studies of cytokines in the pathogenesis of atherosclerosis and its therapeutic measures.
- Author:
Zhi-Ming LI
1
;
Ming-Jie WANG
2
Author Information
1. Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Key Innovation Team of High-Level Local Universities, Fudan University, Shanghai 200032, China.
2. Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Key Innovation Team of High-Level Local Universities, Fudan University, Shanghai 200032, China. mjwang@shmu.edu.cn.
- Publication Type:Review
- MeSH:
Anti-Inflammatory Agents/therapeutic use*;
Atherosclerosis/drug therapy*;
Cytokines;
Humans;
Inflammation/drug therapy*
- From:
Acta Physiologica Sinica
2021;73(3):501-508
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic inflammatory disease. Cytokine-related research provides an important direction for the prevention and treatment of atherosclerosis. Cytokines, produced by different types of cells and acting on a range of targets, play a key role in the pathogenesis and progression of atherosclerosis. This review summarizes the main pro-inflammatory and anti-inflammatory cytokines related to atherosclerosis and their underlying mechanism. We also outline current anti-atherosclerosis treatments targeting cytokines. The research and treatment prospects of cytokines in the prevention and treatment of atherosclerosis are discussed briefly as well.
