Complex mechanisms of chronic pain in knee osteoarthritis identified by neuroimaging technology.
- Author:
Guang-Xin GUO
1
;
Qing-Guang ZHU
2
;
Zi-Ying CHEN
1
;
Yuan-Jia GU
1
;
Fei YAO
1
;
Min FANG
1
Author Information
1. School of Acupuncture-moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
- Publication Type:Journal Article
- MeSH:
Chronic Pain/diagnostic imaging*;
Humans;
Neuroimaging;
Osteoarthritis, Knee/diagnostic imaging*;
Quality of Life;
Technology
- From:
Acta Physiologica Sinica
2021;73(3):423-432
- CountryChina
- Language:Chinese
-
Abstract:
Chronic pain of knee osteoarthritis (KOA) greatly affects the quality of life and functional activities of patients. It is important to clarify the underlying mechanisms of KOA pain and the analgesic effect of different therapies. Neuroimaging technology has been widely used in the basic and clinical research of pain. In the recent years, neuroimaging technology has played an important role in the basic and clinical research of KOA pain. Increasing evidence demonstrates that chronic pain in KOA includes both nociceptive and neuropathic pain. The neuropathic mechanism involved in KOA pain is complex, which may be caused by peripheral or central sensitization. In this paper, we review the regional changes of brain pathophysiology caused by KOA pain based on magnetic resonance imaging (MRI), electroencephalogram (EEG), magnetoencephalogram (MEG), near-infrared spectroscopy (NIRS) and other neuroimaging techniques. We also discuss the central analgesic mechanism of different KOA therapies, with a focus on the latest achievements in the evaluation and prediction of pain. We hope to provide new thoughts for the treatment of KOA pain, especially in the early and middle stages of KOA.
