Oxidative stress in leukemia and antioxidant treatment.
10.1097/CM9.0000000000001628
- VernacularTitle:Oxidative stress in leukemia and antioxidant treatment
- Author:
Chao DONG
1
;
Nai-Jin ZHANG
2
;
Li-Jun ZHANG
1
Author Information
1. Department of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
2. Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
- Publication Type:Review
- MeSH:
Antioxidants/therapeutic use*;
Humans;
Leukemia/drug therapy*;
Oxidative Stress;
Reactive Oxygen Species
- From:
Chinese Medical Journal
2021;134(16):1897-1907
- CountryChina
- Language:English
-
Abstract:
Oxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species (ROS) and the antioxidant defense systems, which can activate various transcription factors and affect their transcriptional pathways. Oxidative stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of leukemia. The standard chemotherapy strategies for the pre-treatment of leukemia have many drawbacks. Hence, the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily applied. This article reviews the research progress of oxidative stress and leukemia. In addition, the application of antioxidants treatment in leukemia has been summarized.
