Association between lung compliance phenotypes and mortality in COVID-19 patients with acute respiratory distress syndrome.
10.47102/annals-acadmedsg.2021129
- Author:
Ser Hon PUAH
1
;
Matthew Edward COVE
;
Jason PHUA
;
Amit KANSAL
;
Jonathen VENKATACHALAM
;
Vui Kian HO
;
Duu Wen SEWA
;
Roshni Sadashiv GOKHALE
;
Mei Fong LIEW
;
Benjamin Choon Heng HO
;
Jensen Jiansheng NG
;
John A ABISHEGANADEN
;
Yee Sin LEO
;
Barnaby Edward YOUNG
;
David Chien LYE
;
Tsin Wen YEO
Author Information
1. Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore.
- Publication Type:Journal Article
- MeSH:
COVID-19;
Humans;
Lung Compliance;
Phenotype;
Respiratory Distress Syndrome/therapy*;
SARS-CoV-2
- From:Annals of the Academy of Medicine, Singapore
2021;50(9):686-694
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with a high mortality rate, though outcomes of the different lung compliance phenotypes are unclear. We aimed to measure lung compliance and examine other factors associated with mortality in COVID-19 patients with ARDS.
METHODS:Adult patients with COVID-19 ARDS who required invasive mechanical ventilation at 8 hospitals in Singapore were prospectively enrolled. Factors associated with both mortality and differences between high (<40mL/cm H
RESULTS:A total of 102 patients with COVID-19 who required invasive mechanical ventilation were analysed; 15 (14.7%) did not survive. Non-survivors were older (median 70 years, interquartile range [IQR] 67-75 versus median 61 years, IQR 52-66;
CONCLUSION:COVID-19 ARDS patients with higher compliance on the day of intubation and a longitudinal decrease over time had a higher risk of death.
