Heterogeneity of non-cystic-fibrosis bronchiectasis in multiethnic Singapore: A prospective cohort study at a tertiary pulmonology centre.
10.47102/annals-acadmedsg.202178
- Author:
Si Ling YOUNG
1
;
Youxin PUAN
;
Si Yuan CHEW
;
Salahudeen Mohamed HAJA MOHIDEEN
;
Pei Yee TIEW
;
Gan Liang TAN
;
Mariko Siyue KOH
;
Ken Cheah Hooi LEE
Author Information
1. Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
- Publication Type:Journal Article
- MeSH:
Aged;
Bronchiectasis/epidemiology*;
Cohort Studies;
Female;
Fibrosis;
Humans;
Male;
Middle Aged;
Prospective Studies;
Pulmonary Medicine;
Severity of Illness Index;
Singapore/epidemiology*
- From:Annals of the Academy of Medicine, Singapore
2021;50(7):556-565
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:Non-cystic fibrosis bronchiectasis (NCFB) is a highly heterogenous disease. We describe the clinical characteristics of NCFB patients and evaluate the performance of Bronchiectasis Severity Index (BSI) in predicting mortality.
METHODS:Patients attending the bronchiectasis clinic between August 2015 and April 2020 with radiologically proven bronchiectasis on computed tomography were recruited. Clinical characteristics, spirometry, radiology, microbiology and clinical course over a median period of 2.4 years is presented.
RESULTS:A total of 168 patients were enrolled in this prospective cohort study. They were predominantly women (67.8%), Chinese (87.5%) and never-smokers (76.9%). Median age of diagnosis was 64 years (interquartile range 56-71) and the most common aetiology was "idiopathic" bronchiectasis (44.6%). Thirty-nine percent had normal spirometries. Compared to female patients, there were more smokers among the male patients (53.8% versus 8.5%,
CONCLUSION:The NCFB cohort in Singapore has unique characteristics with sex differences. Over half the patients had a history of haemoptysis. The BSI score is a useful predictor of mortality in our population.
