New-onset cardiovascular risk factors following liver transplantation: A cohort analysis in Singapore.
10.47102/annals-acadmedsg.2020632
- Author:
Xiao Ying LI
1
;
Hiang Keat TAN
;
Yet Hua LOH
Author Information
1. Department of Dietetics, Singapore General Hospital, Singapore.
- Publication Type:Journal Article
- MeSH:
Cardiovascular Diseases/etiology*;
Heart Disease Risk Factors;
Humans;
Liver Transplantation;
Middle Aged;
Retrospective Studies;
Risk Factors;
Singapore/epidemiology*
- From:Annals of the Academy of Medicine, Singapore
2021;50(7):548-555
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:The aims of this study were to establish weight change, incidence of non-alcoholic fatty liver disease (NAFLD) and cardiovascular risk factors (CvRF) in liver transplant recipients (LTRs).
METHODS:Eighty-three patients whose mean (standard deviation [SD]) age was 55.6 (8.4) years (median follow-up 73 months) and who underwent their first liver transplantation (LT) at Singapore General Hospital between February 2006 and March 2017 were included in the study. Anthropometric, clinical and demographic data were collected retrospectively from patients' medical records. Diabetes mellitus (DM), hyperlipidaemia and hypertension were regarded as CvRF.
RESULTS:Compared to baseline, mean (SD) body weight decreased significantly at 1 month post-LT (60.8kg [11.9] versus 64.3kg [13.7],
CONCLUSION:CvRF increased significantly post-LT, and NAFLD occurred in 25.3% of LTRs. Body weight dropped drastically within the first month post-LT, which then returned to baseline level just before the end of first year. This novel finding suggests that nutritional intervention needs to be tailored and individualised, based on events and time from transplant. Although long-term obesity is a significant problem, aggressive oral or enteral nutritional supplements take precedence in the early and immediate post-LT period, while interventions targeted at metabolic syndrome become necessary after the first year.
