Effect of acupoint thread-embedding on tight junction of intestinal mucosa epithelium in rats with ulcerative colitis.
10.13703/j.0255-2930.20200629-k0003
- Author:
Huan WANG
1
;
Ying ZHU
2
Author Information
1. Yueyang Hospital Affiliated to Hunan University of CM, Yueyang 414000, China.
2. First Affiliated Hospital of Hunan University of CM, Changsha 410007.
- Publication Type:Journal Article
- Keywords:
acupoint thread-embedding;
calmodulin-dependent protein kinaseⅡ(CaMKⅡ);
intestinal mucosa epithelium;
myosin light chain kinase (MLCK);
tight junction;
ulcerative colitis (UC)
- MeSH:
Acupuncture Points;
Animals;
Colitis, Ulcerative/therapy*;
Epithelium;
Intestinal Mucosa;
Male;
Rats;
Rats, Sprague-Dawley;
Tight Junctions
- From:
Chinese Acupuncture & Moxibustion
2021;41(8):899-905
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of acupoint thread-embedding on tight junction of intestinal mucosal epithelial barrier in rats with ulcerative colitis (UC) under the state of "deficiency and stasis", and to explore its mechanism.
METHODS:Sixty male SD rats were randomly divided into a control group (
RESULTS:Compared with the control group, in the model group the body weight was decreased (
CONCLUSION:The thread-embedding could repair the tight junction of intestinal mucosa epithelium and reduce the permeability of intestinal mucosa epithelium, which may be related to the decrease of the expression of CaMKⅡ, MLCK and other protein kinases.
