Systematic Review of Health and Economic Burden Caused by Antibiotic Resistance in China
- VernacularTitle:基于中国背景的细菌耐药所致健康和经济负担的系统评价
- Author:
Yue ZHOU
1
;
Yaoyao YANG
1
;
Xi ZHANG
1
;
Lin HU
1
;
Kexin DU
1
;
Bo ZHENG
2
;
Xiaodong GUAN
1
,
3
;
WUSHOUER HAISHAERJIANG
1
,
3
;
Luwen SHI
1
Author Information
1. Dept. of Pharmacy Administration and Clinical Pharmacy，School of Pharmaceutical Sciences，Peking University，Beijing 100191，China
2. Institute of Clinical Pharmacology，Peking University，Beijing 100191，China
3. International Research Center for Medicinal Administration，Peking University，Beijing 100191，China
- Publication Type:Journal Article
- Keywords:
Bacterial drug resistance;
Health burden;
Economic burden;
Literature;
Systematic review;
China
- From:
China Pharmacy
2021;32(20):2543-2550
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To provide scientific basis for evaluating the burden caused by antibiotic resistance （AbR）and reference for policy making on crubing AbR in China. METHODS ：Databases including CNKI ，Wanfang database ，VIP，PubMed， Scopus，Medline and EconoLite from Jan. 1st 2016 to Aug. 10th 2020 were searched to collect studies on burden caused by AbR in China . After independent literature screening anddata extraction ，Newcastle-Ottawa scale （NOS）was used to evaluate the literature quality ，and a descriptive analysis was conduced to evaluate the health and economic burden caused by AbR. RESULTS ：A total of 27 Chinese and English literatures were included. The NOS scores of i ncluded literatures were 4-6，and all of them were retrospective case-control study ； the patients were divided into case group （resistance infection ） and control group （susceptible infection or non-infection ）； mortality，length of stay and medical expenditure were commonly applied as the measurement indexes. In the included studies ，the mortality of patients infected with AbR bacteria was 0.7-12.0 times that of patients infected with susceptible bacteria ；the mean or medium value of total length of stay was 0.9-2.5 times that of patients infected with susceptible bacteria ；the mean or medium of total medical expenditure was 1.0-2.7 times that of patients with susceptible bacteria infection. The differences in these indicators were greater between patients infected with AbR infections and those without becterial infections. CONCLUSIONS ：Bacterial drug resistance could increase the health and economic burden. However ，the existing relevant studies were mainly single center researches，the sample representation was insufficient ；the research design did not adjust for time-dependent bias ；the repeatability was low ，and the perspective of evalution was limited. It is urgent to carry out multicenter studies with higher quality to comprehensively evaluate the health and economic burden caused by AbR in China.
